Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10362498 | 0.90 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL10489743 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1HPGDNPC1KMT2A | |
| SCHEMBL10362965 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL9508401 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1NPC1KMT2ANPSR1 | |
| SCHEMBL10660264 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1HPGDNPC1KMT2A | |
| SCHEMBL10662510 | 0.76 | NPC1 (0.49) | SMN1; SMN2ALDH1A1NPC1KMT2AAKR1B1 | |
| SCHEMBL9510528 | 0.76 | MAPT (0.43) | SMN1; SMN2ALDH1A1KMT2AAKR1B1NPSR1 | |
| SCHEMBL10489727 | 0.75 | AKR1B1 (0.51) | SMN1; SMN2ALDH1A1HPGDNPC1KMT2A | |
| SCHEMBL10656382 | 0.75 | NPC1 (0.47) | SMN1; SMN2ALDH1A1HPGDNPC1KMT2A | |
| SCHEMBL10657324 | 0.74 | NPC1 (0.58) | SMN1; SMN2ALDH1A1NPC1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |