Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 5/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10489647 | 0.93 | METAP2 (0.57) | METAP2MGLLKDM4EPKMSMN1; SMN2 | |
| SCHEMBL10489785 | 0.91 | METAP2 (0.52) | METAP2MGLLKDM4EPKMSMN1; SMN2 | |
| SCHEMBL10489854 | 0.90 | METAP2 (0.53) | METAP2KDM4EPKMSMN1; SMN2CYP1A2 | |
| SCHEMBL10490025 | 0.88 | CYP1A2 (0.54) | METAP2KDM4EPKMSMN1; SMN2CYP1A2 | |
| SCHEMBL10489898 | 0.86 | METAP2 (0.54) | METAP2KDM4EPKMSMN1; SMN2CYP1A2 | |
| SCHEMBL10489769 | 0.82 | METAP2 (0.57) | METAP2KDM4EPKMLTC4SPLK1 | |
| SCHEMBL10489833 | 0.82 | METAP2 (0.55) | METAP2KDM4EPKMSMN1; SMN2CYP1A2 | |
| SCHEMBL10489746 | 0.82 | METAP2 (0.55) | METAP2KDM4EPKMSMN1; SMN2CYP1A2 | |
| SCHEMBL10875637 | 0.82 | MGLL (0.55) | MGLLKDM4ESMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL10490026 | 0.81 | KDM4E (0.53) | METAP2KDM4EPKMSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873232-A | ARTHRITIS AND AUTOIMMUNE DISEASES | SYNTEX (US) | 1989-10-10 | — | — | US | disclosed |