Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indomethacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 14/20 | 0.69 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | PTGES | O14684 | 1/20 | 0.64 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.64 |
| ▸ | ALB | P02768 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indomethacin SCHEMBL10489820 | 0.95 | PTGS2 (0.66) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489911 | 0.95 | PTGS2 (0.66) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489977 | 0.94 | PTGS2 (0.65) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489917 | 0.93 | PTGS2 (0.63) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489962 | 0.86 | PTGS2 (0.69) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489926 | 0.86 | PTGS2 (0.69) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489923 | 0.84 | PTGS2 (0.66) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| SCHEMBL12989547 | 0.83 | PTGS2 (0.77) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL10489980 | 0.83 | PTGS2 (0.94) | PTGS2HIF1ALMNACYP1A2CYP2D6 | |
| Indomethacin SCHEMBL19611298 | 0.82 | PTGS2 (0.82) | PTGS2HIF1ALMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847260-A | NICOTINIC AND ISONITINIC ESTER ANTIARRHYTHMIA AGENTS FOR SKINS | NITTO DENKO CORPORATION (JP) | 1989-07-11 | — | — | US | disclosed |