Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indomethacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 9/20 | 0.94 |
| ▸ | PTGS1 known ✓ | P23219 | 4/20 | 0.94 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.94 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.94 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.94 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.94 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.94 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.94 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.94 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | PTGES | O14684 | 1/20 | 0.94 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.94 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.94 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indomethacin SCHEMBL9630386 | 0.99 | PTGS2 (0.92) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL9300 | 0.97 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL29525957 | 0.97 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL29353712 | 0.97 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL3518614 | 0.97 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23391006 | 0.96 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL6554617 | 0.96 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL6356562 | 0.96 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL1817813 | 0.96 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL22472310 | 0.96 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112546240-B | Cyclodextrin metal organic framework composition for improving dissolution of indometacin | 中国药科大学 | 2022-08-30 | — | — | CN | claimed |
| CN-112546240-A | Cyclodextrin metal organic framework composition for improving dissolution of indometacin | 中国药科大学 | 2021-03-26 | — | — | CN | claimed |
| CN-1543947-A | Novel use of indomethacin and its external applied preparation for treating cutaneous pruritus | 张晓军 | 2004-11-10 | — | — | CN | claimed |
| CN-112546240-B | Cyclodextrin metal organic framework composition for improving dissolution of indometacin | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-113244438-B | Preparation method of three-dimensional functional medical dressing for diabetic foot ulcer | 五邑大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-113244438-A | Preparation method of three-dimensional functional medical dressing for diabetic foot ulcer | 五邑大学 | 2021-08-13 | — | — | CN | disclosed |
| CN-112546240-A | Cyclodextrin metal organic framework composition for improving dissolution of indometacin | 中国药科大学 | 2021-03-26 | — | — | CN | disclosed |
| CN-110687069-A | Microfluidic-based high-throughput crystallization condition screening method | 中山大学 | 2020-01-14 | — | — | CN | disclosed |
| US-9808443-B1 | Cyclooxygenase inhibitors | KING SAUD UNIVERSITY (SA) | 2017-11-07 | — | — | US | disclosed |
| CN-102335284-B | Externally applied health care product for recovery of female cauliflower excrescence | SU YANG | 2013-03-27 | — | — | CN | disclosed |
| CN-102335284-A | Externally applied health care product for recovery of female cauliflower excrescence | YANG SU | 2012-02-01 | — | — | CN | disclosed |
| CN-1237967-C | Novel use of indomethacin and its external applied preparation for treating cutaneous pruritus | ZHANG XIAOJUN (CN) | 2006-01-25 | — | — | CN | disclosed |
| CN-1543947-A | Novel use of indomethacin and its external applied preparation for treating cutaneous pruritus | 张晓军 | 2004-11-10 | — | — | CN | disclosed |
| US-4863952-A | Method of promoting percutaneous drug absorption with 2-pyrrolidin-2-one 5-carboxylic acids and esters thereof | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4847260-A | NICOTINIC AND ISONITINIC ESTER ANTIARRHYTHMIA AGENTS FOR SKINS | NITTO DENKO CORPORATION (JP) | 1989-07-11 | — | — | US | disclosed |
| US-4732916-A | ANTIULCER AGENTS | KABUSHIKI KAISHA MED-CREAT (JP) | 1988-03-22 | — | — | US | disclosed |