Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL2286625 | 0.91 | NPSR1 (0.50) | FFAR1NPSR1NPC1RAB9AASIC3 | |
| Guanidine SCHEMBL2281423 | 0.90 | LMNA (0.39) | FFAR1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9629232 | 0.88 | FFAR1 (0.50) | FFAR1GABRPGABRDGABRA1GABRB1 | |
| Guanidine SCHEMBL10363125 | 0.83 | KMT2A (0.64) | NPC1RAB9A | |
| SCHEMBL10788584 | 0.82 | APP (0.56) | FFAR1GABRPGABRDGABRA1GABRB1 | |
| Guanidine SCHEMBL10792358 | 0.79 | FFAR1 (0.38) | FFAR1GABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL6653836 | 0.79 | APP (0.53) | FFAR1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL68968 | 0.78 | NPSR1 (0.59) | FFAR1NPSR1NPC1RAB9AVCP | |
| Benzene SCHEMBL28174766 | 0.78 | NPSR1 (0.59) | FFAR1NPSR1NPC1RAB9AVCP | |
| Guanidine SCHEMBL10630419 | 0.78 | PTGDR2 (0.39) | FFAR1GABRA1GABRG2GABRB3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859568-A | Photographic image recording method using silver halide and vinyl monomer | FUJI PHOTO FILM CO., LTD. (JP) | 1989-08-22 | — | — | US | disclosed |