Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8579882 | 0.89 | CYP3A4 (0.38) | TDP1ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6229251 | 0.85 | CACNA2D1 (0.43) | TDP1ALDH1A1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL8130850 | 0.82 | CYP3A4 (0.43) | TDP1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11410686 | 0.82 | CACNA2D1 (0.43) | TDP1ALDH1A1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL6225152 | 0.79 | CACNA2D1 (0.41) | TDP1ALDH1A1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22044345 | 0.79 | TP53 (0.45) | TDP1ALDH1A1CACNA1CTP53MAPT | |
| Dimethylamine SCHEMBL10775328 | 0.78 | CYP3A4 (0.39) | TDP1ALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL28359145 | 0.75 | CACNA2D1 (0.41) | TDP1ALDH1A1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22044344 | 0.75 | ALDH1A1 (0.45) | TDP1ALDH1A1TP53MAPTSMN1; SMN2 | |
| SCHEMBL28204747 | 0.75 | TP53 (0.45) | TDP1ALDH1A1CACNA1CTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868225-A | STERICALLY HINDERED META-PHENYLENEDIAMINE CHAIN EXTENDER FOR POLYURETHANES | THE DOW CHEMICAL COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4866208-A | CURING AGENT FOR EPOXY RESINS; EXTENDERS FOR POLYUREA-URETHANE COPOLYMERS | THE DOW CHEMICAL COMPANY (US) | 1989-09-12 | — | — | US | disclosed |
| US-4792623-A | CURING AGENT, EXTENDER | THE DOW CHEMICAL COMPANY (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0082258-B1 | SUBSTITUTED M-PHENYLENEDIAMINES | THE DOW CHEMICAL COMPANY (US) | 1986-02-19 | — | — | EP | disclosed |
| EP-0082258-A1 | Substituted m-phenylenediamines | THE DOW CHEMICAL COMPANY (US) | 1983-06-29 | — | — | EP | disclosed |