Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.66 |
| ▸ | DAO | P14920 | 4/20 | 0.59 |
| ▸ | TYR | P14679 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10494181 | 1.00 | ELANE (0.66) | ELANEDAOTYRKDM4E | |
| SCHEMBL10494163 | 1.00 | ELANE (0.66) | ELANEDAOTYRKDM4E | |
| SCHEMBL9625178 | 0.94 | DAO (0.62) | ELANEDAOTYRKDM4E | |
| SCHEMBL9625602 | 0.88 | DAO (0.66) | ELANEDAOTYRKDM4E | |
| SCHEMBL11036240 | 0.82 | ELANE (0.48) | ELANEDAOTYR | |
| SCHEMBL3258342 | 0.82 | DAO (0.70) | ELANEDAOTYRKDM4E | |
| SCHEMBL30982893 | 0.80 | TYR (0.64) | ELANEDAOTYRKDM4E | |
| SCHEMBL10494160 | 0.77 | ELANE (0.72) | ELANE | |
| SCHEMBL10494153 | 0.77 | ELANE (0.72) | ELANE | |
| SCHEMBL10494194 | 0.77 | ELANE (0.74) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4812474-A | ELASTASE INHIBITORY ANTIINFLAMMATORY AGENT | G. D. SEARLE & CO. (US) | 1989-03-14 | — | — | US | disclosed |
| US-4735964-A | ELASTASE INHIBITORS; ANTI INFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1988-04-05 | — | — | US | disclosed |
| US-4603144-A | Kojic acid ether-ester derivatives | G. D. SEARLE & CO. (US) | 1986-07-29 | — | — | US | disclosed |