Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | RHOC | P08134 | 1/20 | 0.56 |
| ▸ | RHOA | P61586 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10495125 | 0.99 | NPC1 (0.77) | NPC1TSHRUSP2ALOX15MAPK1 | |
| SCHEMBL10495055 | 0.87 | NPC1 (0.82) | NPC1TSHRUSP2ALOX15MAPK1 | |
| SCHEMBL24272429 | 0.86 | NPC1 (0.71) | NPC1RAB9AHPGDSMN1; SMN2RHOC | |
| SCHEMBL10495041 | 0.85 | NPC1 (0.62) | NPC1TSHRUSP2ALOX15MAPK1 | |
| SCHEMBL10495004 | 0.84 | NPC1 (0.78) | NPC1RAB9AHPGDSMN1; SMN2RHOC | |
| SCHEMBL10495010 | 0.84 | NPC1 (0.73) | NPC1TSHRRAB9AHPGDSMN1; SMN2 | |
| SCHEMBL10495115 | 0.84 | NPC1 (0.64) | NPC1TSHRUSP2ALOX15MAPK1 | |
| SCHEMBL10495056 | 0.84 | RAB9A (0.65) | NPC1TSHRUSP2ALOX15MAPK1 | |
| SCHEMBL10495065 | 0.84 | NPC1 (0.88) | NPC1TSHRUSP2ALOX15MAPK1 | |
| SCHEMBL10495168 | 0.84 | NPC1 (0.59) | NPC1TSHRUSP2ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831055-A | ANTILIPEMIC AND ANTICHOLESTEROL AGENTS | NIPPON SHINYAKU CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |