Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | RXRB | P28702 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10495055 | 0.88 | NPC1 (0.82) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10495144 | 0.86 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2HPGDHSP90AA1 | |
| SCHEMBL10495056 | 0.85 | RAB9A (0.65) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10495065 | 0.85 | NPC1 (0.88) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10495125 | 0.85 | NPC1 (0.77) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10495015 | 0.84 | NPC1 (0.75) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10494994 | 0.83 | NPC1 (0.82) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL11446543 | 0.82 | RXRA (0.57) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10495017 | 0.82 | NPC1 (0.63) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL9339620 | 0.81 | RXRA (0.56) | NPC1USP2ALOX15TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831055-A | ANTILIPEMIC AND ANTICHOLESTEROL AGENTS | NIPPON SHINYAKU CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |