SCHEMBL1049554

SCHEMBL1049554

COCCOc1ccc(F)c(C=O)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.40
ALDH1A1 P00352 6/20 0.39
FLT1 P17948 2/20 0.36
KDR P35968 2/20 0.36
EGFR P00533 2/20 0.36
S1PR4 O95977 2/20 0.36
MAPT P10636 4/20 0.36
HPGD P15428 4/20 0.36
HTR2C P28335 3/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
HTR2B P41595 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
MAPK1 P28482 2/20 0.35
HTT P42858 2/20 0.35
LMNA P02545 1/20 0.35
TDP1 Q9NUW8 2/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2248374 0.84 HTR2C (0.45) ALDH1A1S1PR4HPGDHTR2CL3MBTL1
SCHEMBL6907326 0.83 TACR2 (0.43) ALDH1A1MAPTHPGDL3MBTL1CYP2C9
SCHEMBL14147611 0.82 FDPS (0.40) FDPSALDH1A1EGFRS1PR4MAPT
SCHEMBL3363639 0.81 FDPS (0.41) FDPSALDH1A1EGFRMAPTHPGD
SCHEMBL2251133 0.81 DRD1 (0.37) FDPSALDH1A1S1PR4MAPTHPGD
SCHEMBL2253680 0.80 ERN1 (0.42) ALDH1A1S1PR4MAPTHPGDHTR2C
SCHEMBL23723813 0.79 FLT1 (0.35) FDPSALDH1A1FLT1KDREGFR
SCHEMBL30013891 0.79 FLT1 (0.35) FDPSALDH1A1FLT1KDREGFR
SCHEMBL13996312 0.78 ALDH1A1 (0.44) FDPSALDH1A1EGFRHPGDL3MBTL1
SCHEMBL1052544 0.77 EPAS1 (0.40) ALDH1A1MAPTL3MBTL1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4100124-A1 HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS Janssen Biotech, Inc. (US) 2022-12-14 EP disclosed
CN-115427109-A Heterocyclic compounds as dihydroorotate dehydrogenase inhibitors 詹森生物科技公司 2022-12-02 CN disclosed
WO-2021156787-A1 HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS JANSSEN BIOTECH, INC. (US) 2021-08-12 WO disclosed
US-7872018-B2 Compounds and methods for kinase modulation, and indications therefor PLEXXIKON, INC. (US) 2011-01-18 US disclosed
US-7872018-B2 Compounds and methods for kinase modulation, and indications therefor PLEXXIKON, INC. (US) 2011-01-18 US disclosed
US-7872018-B2 Compounds and methods for kinase modulation, and indications therefor PLEXXIKON, INC. (US) 2011-01-18 US disclosed
EP-2094701-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2009-09-02 EP disclosed
US-20080221148-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC 2008-09-11 US disclosed
US-20080221148-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC 2008-09-11 US disclosed
US-20080221148-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC 2008-09-11 US disclosed
WO-2008080001-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2008-07-03 WO disclosed
WO-2008080001-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2008-07-03 WO disclosed
WO-2008080015-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2008-07-03 WO disclosed
WO-2008080015-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2008-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080221148-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, MAP3K13, MAP3K8 FDPS 1294/4885ALDH1A1 4348/4885FLT1 1223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.