Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | NAMPT | P43490 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14509638 | 0.83 | ATM (0.77) | L3MBTL1ATMNAMPTALDH1A1TSHR | |
| SCHEMBL17203603 | 0.83 | ATM (0.77) | L3MBTL1ATMNAMPTALDH1A1TSHR | |
| SCHEMBL6034582 | 0.82 | ATM (0.97) | L3MBTL1ATMNAMPTKMT2A | |
| SCHEMBL10496019 | 0.82 | ATM (0.76) | L3MBTL1ATMNAMPTTSHRKMT2A | |
| SCHEMBL5250912 | 0.82 | ATM (0.75) | L3MBTL1ATMNAMPTALDH1A1KMT2A | |
| SCHEMBL20389348 | 0.81 | NAMPT (1.00) | L3MBTL1NAMPT | |
| SCHEMBL4059362 | 0.76 | ATM (0.66) | L3MBTL1ATMNAMPTALDH1A1GAA | |
| SCHEMBL12335292 | 0.75 | ATM (0.59) | L3MBTL1ATMNAMPTALDH1A1TSHR | |
| SCHEMBL17213926 | 0.75 | ATM (0.71) | L3MBTL1ATMNAMPTTSHRKMT2A | |
| SCHEMBL2848205 | 0.75 | L3MBTL1 (0.60) | L3MBTL1ATMNAMPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734510-A | HYPOTENSIVE AGENTS | JOHN WYETH & BROTHER LIMITED (GB) | 1988-03-29 | — | — | US | claimed |
| US-4808715-A | HYPERTENSIVE AGENTS | JOHN WYETH & BROTHER LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| US-4734510-A | HYPOTENSIVE AGENTS | JOHN WYETH & BROTHER LIMITED (GB) | 1988-03-29 | — | — | US | disclosed |
| US-4640920-A | HYPOTENSIVE AGENTS | JOHN WYETH & BROTHER LIMITED (GB) | 1987-02-03 | — | — | US | disclosed |