Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10496199 | 1.00 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL5171500 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL14509872 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL9441772 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL10858190 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL10858196 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL9441769 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL9441722 | 0.81 | ALDH1A1 (0.42) | PTGS2PTGS1 | |
| SCHEMBL9441751 | 0.80 | PTGS2 (0.41) | PTGS2 | |
| SCHEMBL9441746 | 0.80 | PTGS2 (0.41) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068038-A1 | (+)-(4R,6S)-(E)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | claimed |
| US-RE33033-E | REACTING AND ALDEHYDE WITH ENOLATE OF AN ALKYLACETATE; HYDROLYSIS | MERCK & CO., INC. (US) | 1989-08-22 | — | — | US | disclosed |
| EP-0207456-A2 | Process for the preparation of HMG-CoA reductase inhibitors intermediates | MERCK & CO. INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| US-4620025-A | NICKEL COMPLEX CATALYSTS | MERCK & CO., INC. (US) | 1986-10-28 | — | — | US | disclosed |
| US-4611081-A | Process for the preparation of HMG-CoA reductase inhibitors intermediates | MERCK & CO., INC. (US) | 1986-09-09 | — | — | US | disclosed |
| US-4582914-A | STEREOSPECIFIC PREPARATION OF 3-HYDROXY-3-METHYLGLUTARYLCOENZYME A, A COMPACTIN AND MEVINOLIN DERIVATIVE | MERCK & CO., INC. (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0068038-B1 | (+)-(4R,6S)-(E)-6-(2-(4'-FLUORO-3,3',5-TRIMETHYL-(1,1'-BIPHENYL)-2-YL)ETHENYL)-3,4,5,6-TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONE, A PROCESS FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1985-09-25 | — | — | EP | disclosed |