SCHEMBL10498166

SCHEMBL10498166

COC(=O)c1sccc1S(=O)(=O)NC(=O)Nc1nc(C)cc(OC(F)F)n1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 3/20 0.42
GAA P10253 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CDK1 P06493 1/20 0.38
FBP1 P09467 1/20 0.37
MAPT P10636 1/20 0.37
PPARG P37231 1/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
KCNH2 Q12809 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10498516 0.91 GAA (0.52) EDNRAGAAMEN1KMT2ACDK1
SCHEMBL10753757 0.89 GAA (0.50) EDNRAGAAMEN1KMT2ACDK1
SCHEMBL10754167 0.88 EDNRA (0.49) EDNRAGAAMEN1KMT2AMAPT
SCHEMBL10751011 0.83 GAA (0.46) EDNRAGAAMEN1KMT2ACDK1
SCHEMBL10752205 0.83 GAA (0.57) EDNRAGAAMEN1KMT2ACDK1
SCHEMBL10455721 0.83 GAA (0.43) GAAMEN1KMT2ACDK1MAPT
SCHEMBL10498570 0.82 GAA (0.40) GAACDK1FBP1MAPT
SCHEMBL10758244 0.81 GAA (0.50) EDNRAGAACDK1MAPT
SCHEMBL10752070 0.81 EDNRA (0.50) EDNRAGAAMEN1KMT2AMAPT
SCHEMBL10743535 0.79 GAA (0.45) GAAKMT2AFBP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0097122-B1 N-HETEROCYCLOSULFONYL-N'-PYRIMIDINYL AND TRIAZINYL UREAS CIBA-GEIGY AG (CH) 1989-05-31 EP claimed
US-4549898-A PREEMERGENT AND POSTEMERGENT HERBICIDES CIBA-GEIGY CORPORATION (US) 1985-10-29 US claimed
US-4549898-A PREEMERGENT AND POSTEMERGENT HERBICIDES CIBA-GEIGY CORPORATION (US) 1985-10-29 US disclosed