SCHEMBL10498570

SCHEMBL10498570

COC(=O)c1cscc1S(=O)(=O)NC(=O)Nc1nc(C)cc(OC(F)F)n1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.40
CDK1 P06493 1/20 0.37
FBP1 P09467 1/20 0.36
ALOX15 P16050 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
ALDH1A1 P00352 2/20 0.32
LMNA P02545 2/20 0.32
MAPT P10636 1/20 0.32
HIF1A Q16665 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10498343 0.91 GAA (0.50) GAACDK1FBP1ALDH1A1MAPT
SCHEMBL11100249 0.89 GAA (0.48) GAACDK1ALOX15ALDH1A1LMNA
SCHEMBL11100645 0.88 GAA (0.44) GAACDK1ALOX15ALDH1A1LMNA
SCHEMBL10455721 0.85 GAA (0.43) GAACDK1NPC1MAPTTSHR
SCHEMBL11100011 0.82 GAA (0.55) GAACDK1ALDH1A1MAPT
SCHEMBL10498166 0.82 EDNRA (0.42) GAACDK1FBP1MAPT
SCHEMBL11100056 0.81 GAA (0.48) GAACDK1ALOX15ALDH1A1LMNA
SCHEMBL11104340 0.80 GAA (0.38) GAACDK1FBP1NPC1ALDH1A1
SCHEMBL9140753 0.79 GAA (0.48) GAACDK1NPC1MAPT
SCHEMBL29508602 0.79 GAA (0.48) GAACDK1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0097122-B1 N-HETEROCYCLOSULFONYL-N'-PYRIMIDINYL AND TRIAZINYL UREAS CIBA-GEIGY AG (CH) 1989-05-31 EP claimed
US-4549898-A PREEMERGENT AND POSTEMERGENT HERBICIDES CIBA-GEIGY CORPORATION (US) 1985-10-29 US claimed
US-4549898-A PREEMERGENT AND POSTEMERGENT HERBICIDES CIBA-GEIGY CORPORATION (US) 1985-10-29 US disclosed