Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Strychnine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 14/20 | 0.90 |
| ▸ | GLRB | P48167 | 14/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.90 |
| ▸ | MEN1 | O00255 | 2/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.90 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.90 |
| ▸ | SCN1A | P35498 | 1/20 | 0.90 |
| ▸ | TAS2R46 | P59540 | 1/20 | 0.90 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.90 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Strychnine SCHEMBL1049901 | 1.00 | GLRA1 (0.90) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29888864 | 1.00 | GLRA1 (0.90) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29362678 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL21985190 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL14047653 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29352583 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL14117483 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL12549549 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL93798 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL14029424 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1102989-A | Antiepilepsy medicine and preparing method | TIEXI NEUROPSYCHOSIS HOSPITAL (CN) | 1995-05-31 | — | — | CN | claimed |
| US-3960757-A | HYDROPHOBIC | TOYO JOZO CO., LTD. (JA) | 1976-06-01 | — | — | US | claimed |
| EP-4653499-A2 | SILICONE MATERIAL, SILICONE TUBE, IMPLANT, PHARMACEUTICAL COMPOSITION, AND TEST METHOD FOR AMOUNT OF DRUG RELEASED | SHENYANG XINGHUA PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2025-11-26 | — | — | EP | disclosed |
| US-20250205385-A1 | SILICONE MATERIAL, SILICONE TUBE, IMPLANT, PHARMACEUTICAL COMPOSITION, AND TEST METHOD FOR AMOUNT OF DRUG RELEASED | SHENYANG XINGHUA PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2025-06-26 | — | — | US | disclosed |
| CN-119970889-A | Processing method for reducing toxicity of rhizoma arisaematis | 河北大学 | 2025-05-13 | — | — | CN | disclosed |
| CN-119656097-A | Pharmaceutical composition, rod core and implant, and preparation method and application thereof | 沈阳药科大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-119656096-A | Medicine carrying rod core and raw material composition, implant and preparation and application thereof | 沈阳药科大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-119662025-A | Silica gel material and preparation method thereof, silica gel tube and implant, and preparation method and application thereof | 沈阳药科大学 | 2025-03-21 | — | — | CN | disclosed |
| WO-2025056040-A1 | PHARMACEUTICAL COMPOSITION, DRUG-LOADED ROD CORE, IMPLANT, PREPARATION METHOD THEREFOR, AND USE THEREOF | 沈阳星华医药科技有限公司 | 2025-03-20 | — | — | WO | disclosed |
| WO-2025056039-A1 | SILICONE MATERIAL, SILICONE TUBE, IMPLANT AND PREPARATION METHOD THEREFOR, ROD CORE, PERFORATED IMPLANT AND PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳星华医药科技有限公司 | 2025-03-20 | — | — | WO | disclosed |
| CN-118716623-B | Composition for improving sleep and memory and preparation method and application thereof | 浙江衡美健康科技股份有限公司 | 2024-12-20 | — | — | CN | disclosed |
| EP-0635218-A1 | TASTE MODIFYING METHOD AND BITTER TASTE REDUCING METHOD | Kao Corporation (JP) | 1995-01-25 | — | — | EP | disclosed |
| EP-0631787-A2 | Method for suppressing bitter taste of oral preparation | Kao Corporation (JP) | 1995-01-04 | — | — | EP | disclosed |
| CN-1078906-A | Prevent and treat the compound method and the application thereof of tetanus Chinese herbal medicine | FANG SIBING (CN) | 1993-12-01 | — | — | CN | disclosed |
| EP-0423524-A2 | Propiophenone derivatives and their preparation and pharmaceutical use | MARUHO Co., Ltd. (JP) | 1991-04-24 | — | — | EP | disclosed |
| US-4810709-A | ANTIHYPOXIC, ANTICONVULSANT | RICHTER GEDEON VEGYESZEFI GYAR R.T. (HU) | 1989-03-07 | — | — | US | disclosed |
| US-4677109-A | ANTISPASMODIC, ANTIPYRETIC AND ANTIACUTE ALCOHOLIC INTOXICATION | Richter Gedeon Vegyeszeti Syar R.T. (HU) | 1987-06-30 | — | — | US | disclosed |
| CN-85106416-A | Preparation nitro A Piao vincamine acid derivative and the method that contains the medicinal compositions of this analog derivative | — | 1987-03-18 | — | — | CN | disclosed |
| US-4494245-A | Techniques for repelling predatory animals by the use of aposematic patterns and coloration | BURKHEAD NOEL M | 1985-01-22 | — | — | US | disclosed |
| US-3960757-A | HYDROPHOBIC | TOYO JOZO CO., LTD. (JA) | 1976-06-01 | — | — | US | disclosed |