Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22170892 | 0.88 | NAAA (0.48) | HTR1ADRD4DRD2ITGB3ITGA2B | |
| SCHEMBL16768104 | 0.85 | HTR1A (0.45) | HTR1ADRD4DRD2HDAC3HDAC1 | |
| SCHEMBL4679015 | 0.80 | NAAA (0.50) | ITGB3ITGA2BNAAAEPHX1SMN1; SMN2 | |
| SCHEMBL4678443 | 0.80 | NAAA (0.55) | ITGB3ITGA2BNAAAEPHX1SMN1; SMN2 | |
| SCHEMBL9558337 | 0.79 | HTR1A (0.42) | HTR1ADRD4DRD2NAAAALDH1A1 | |
| SCHEMBL10304069 | 0.78 | NAAA (0.68) | NAAAEPHX1GNAI3GNAO1GNAI1 | |
| SCHEMBL23419143 | 0.78 | NAAA (0.58) | ITGB3ITGA2BNAAAEPHX1SMN1; SMN2 | |
| SCHEMBL61158 | 0.78 | NAAA (0.58) | ITGB3ITGA2BNAAAEPHX1SMN1; SMN2 | |
| SCHEMBL19550760 | 0.77 | HDAC3 (0.45) | HTR1ADRD4DRD2HDAC3HDAC1 | |
| SCHEMBL19551083 | 0.77 | HDAC3 (0.45) | HTR1ADRD4DRD2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0105838-B1 | 3-AMINOPROPOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Louis, William John (AU) | 1989-06-21 | — | — | EP | disclosed |
| US-4661513-A | 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them | Louis, William John (AU) | 1987-04-28 | — | — | US | disclosed |
| EP-0105838-A1 | 3-Aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them | Louis, William John (AU) | 1984-04-18 | — | — | EP | disclosed |