Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 18/20 | 0.82 |
| ▸ | CA2 | P00918 | 18/20 | 0.82 |
| ▸ | CA12 | O43570 | 17/20 | 0.82 |
| ▸ | CA9 | Q16790 | 17/20 | 0.82 |
| ▸ | CA3 | P07451 | 15/20 | 0.82 |
| ▸ | CA6 | P23280 | 15/20 | 0.82 |
| ▸ | CA7 | P43166 | 15/20 | 0.82 |
| ▸ | CA5B | Q9Y2D0 | 15/20 | 0.82 |
| ▸ | CA4 | P22748 | 14/20 | 0.82 |
| ▸ | CA14 | Q9ULX7 | 14/20 | 0.82 |
| ▸ | CA13 | Q8N1Q1 | 13/20 | 0.82 |
| ▸ | CA5A | P35218 | 11/20 | 0.82 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10498914 | 0.98 | CA1 (0.79) | CA1CA2CA12CA9CA3 | |
| SCHEMBL1809228 | 0.90 | CA1 (1.00) | CA1CA2CA12CA9CA3 | |
| SCHEMBL10575436 | 0.87 | CA1 (0.74) | CA1CA2CA12CA9CA3 | |
| SCHEMBL13284043 | 0.85 | CA1 (0.72) | CA1CA2CA12CA9CA3 | |
| SCHEMBL10685397 | 0.78 | CA12 (0.73) | CA1CA2CA12CA9CA3 | |
| SCHEMBL31717970 | 0.78 | CA12 (1.00) | CA1CA2CA12CA9CA3 | |
| SCHEMBL574023 | 0.78 | CA12 (1.00) | CA1CA2CA12CA9CA3 | |
| SCHEMBL15076647 | 0.78 | CA1 (0.72) | CA1CA2CA12CA9CA3 | |
| SCHEMBL5014186 | 0.78 | CA1 (0.70) | CA1CA2CA12CA9CA3 | |
| SCHEMBL2502851 | 0.78 | CA12 (0.48) | CA1CA2CA12CA9CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0111397-B1 | ISOINDOLE DERIVATIVES, PREPARATION, AND USES | Bristol-Myers Company (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4600758-A | 5-SULFAMOYL-3-OXOISOINDOLES WITH ARLYPIPERIDINYL MOIETIES, DIURETICS, HYPOTENSIVES | MEAD JOHNSON & COMPANY (US) | 1986-07-15 | — | — | US | disclosed |
| US-4495194-A | HYPOTENSIVE AGENTS; DIURETICS | MEAD JOHNSON & COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0111397-A1 | Isoindole derivatives, preparation, and uses | Bristol-Myers Company (US) | 1984-06-20 | — | — | EP | disclosed |