Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502019 | 0.83 | CDC7 (0.39) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL10500916 | 0.80 | PDE3B (0.51) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL10501501 | 0.75 | PDE3B (0.41) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL7680971 | 0.69 | CYP3A4 (0.67) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL8737044 | 0.66 | CYP19A1 (0.59) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL10501015 | 0.66 | SMN1; SMN2 (0.50) | CYP3A4CYP11B1CYP17A1PDE10AKDM4E | |
| SCHEMBL7430671 | 0.66 | PDE3B (0.67) | CYP3A4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9787246 | 0.64 | CYP3A4 (0.39) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL23882753 | 0.63 | CYP3A4 (0.50) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL23882826 | 0.63 | CYP3A4 (0.50) | CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4803278-A | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |