Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502053 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAL3MBTL1GAATSHR | |
| SCHEMBL10502019 | 0.81 | CDC7 (0.39) | CYP17A1CYP11B1KDM4EMAPTHSD17B10 | |
| SCHEMBL10501097 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAL3MBTL1GAATSHR | |
| SCHEMBL1242879 | 0.73 | SMN1; SMN2 (0.87) | SMN1; SMN2LMNAL3MBTL1GAATSHR | |
| SCHEMBL12925891 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAL3MBTL1GAATSHR | |
| SCHEMBL10501673 | 0.72 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAL3MBTL1GAATSHR | |
| SCHEMBL10501352 | 0.71 | PRKAB2 (0.44) | SMN1; SMN2LMNAGAACYP11B1MAPT | |
| SCHEMBL10501018 | 0.71 | LMNA (0.49) | SMN1; SMN2LMNAL3MBTL1GAATSHR | |
| SCHEMBL4098469 | 0.69 | — | — | |
| SCHEMBL177932 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4803278-A | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |