Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16405009 | 0.98 | PTGS2 (0.36) | LMNAMAPK1PTGS2CYP3A4GPR35 | |
| SCHEMBL14107135 | 0.98 | PTGS2 (0.36) | LMNAMAPK1PTGS2CYP3A4GPR35 | |
| SCHEMBL12925772 | 0.88 | PTGS2 (0.42) | LMNAPTGS2CYP3A4GPR35ALDH1A1 | |
| SCHEMBL26816216 | 0.86 | HSD17B10 (0.33) | MAPK1ALDH1A1MAPT | |
| SCHEMBL15926111 | 0.82 | GPR35 (0.35) | PTGS2GPR35 | |
| SCHEMBL14930088 | 0.82 | GPR35 (0.32) | GPR35 | |
| SCHEMBL19267449 | 0.81 | GPR35 (0.34) | PTGS2GPR35 | |
| SCHEMBL12263242 | 0.81 | PTGS2 (0.37) | PTGS2CYP3A4GPR35ALDH1A1 | |
| SCHEMBL18643477 | 0.80 | PTGS2 (0.32) | LMNAMAPK1PTGS2GPR35MAPT | |
| SCHEMBL26453190 | 0.79 | PTGS2 (0.33) | LMNAMAPK1PTGS2CYP3A4GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144013-B1 | THIENOTHIOPHENE DERIVATIVES | MERCK PATENT GmbH (DE) | 1989-01-18 | — | — | EP | disclosed |