Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502325 | 0.87 | POLB (0.38) | ALDH1A1CYP1A2KDM4EMAPTTDP1 | |
| SCHEMBL29864658 | 0.69 | MAPT (0.55) | ALDH1A1CYP1A2KDM4EMAPTPOLB | |
| SCHEMBL3048607 | 0.69 | MAPT (0.55) | ALDH1A1CYP1A2KDM4EMAPTPOLB | |
| SCHEMBL10568546 | 0.68 | MAPT (0.49) | ALDH1A1CYP1A2KDM4EMAPTTDP1 | |
| SCHEMBL7440629 | 0.68 | PDE3B (0.59) | ALDH1A1PDE3BPDE3APOLBKMT2A | |
| Hydrochloric Acid SCHEMBL10324019 | 0.67 | MAPT (0.53) | ALDH1A1CYP1A2KDM4EMAPTPOLB | |
| SCHEMBL28799220 | 0.67 | MAPT (0.53) | ALDH1A1CYP1A2KDM4EMAPTPOLB | |
| SCHEMBL7268370 | 0.66 | KCNA5 (0.52) | ALDH1A1CYP1A2KDM4EGAATP53 | |
| SCHEMBL31744336 | 0.66 | KCNA5 (0.52) | ALDH1A1CYP1A2KDM4EGAATP53 | |
| SCHEMBL29767197 | 0.66 | KCNA5 (0.52) | ALDH1A1CYP1A2KDM4EGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4803278-A | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |