Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048607 | 0.73 | MAPT (0.55) | MAPTKDM4EALDH1A1TP53MEN1 | |
| SCHEMBL29864658 | 0.73 | MAPT (0.55) | MAPTKDM4EALDH1A1TP53MEN1 | |
| Hydrochloric Acid SCHEMBL10324019 | 0.71 | MAPT (0.53) | MAPTKDM4EALDH1A1TP53MEN1 | |
| SCHEMBL28799220 | 0.71 | MAPT (0.53) | MAPTKDM4EALDH1A1TP53MEN1 | |
| SCHEMBL10501673 | 0.71 | SMN1; SMN2 (0.51) | MAPTKDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20878330 | 0.69 | GAA (0.39) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL10501719 | 0.68 | ALDH1A1 (0.40) | MAPTKDM4EALDH1A1TDP1TP53 | |
| SCHEMBL4061357 | 0.67 | MAPT (0.46) | MAPTKDM4EALDH1A1TP53MEN1 | |
| SCHEMBL23610057 | 0.66 | SLC6A2 (0.63) | MAPTKDM4EALDH1A1CYP2C19SLC6A2 | |
| SCHEMBL10324020 | 0.66 | MAPT (0.49) | MAPTKDM4EALDH1A1TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4803278-A | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |