Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501719 | 0.87 | ALDH1A1 (0.40) | POLBKCNA5ALDH1A1MAPTKDM4E | |
| SCHEMBL10501501 | 0.78 | PDE3B (0.41) | POLBALDH1A1MAPTKDM4EAPLNR | |
| SCHEMBL10502059 | 0.71 | POLB (0.46) | POLBALDH1A1KDM4EAPLNRALOX12 | |
| SCHEMBL7275282 | 0.67 | KCNA5 (0.50) | KCNA5ALDH1A1KDM4ECYP2C19KCNH2 | |
| SCHEMBL1526122 | 0.67 | KCNA5 (0.50) | KCNA5ALDH1A1KDM4ECYP2C19KCNH2 | |
| SCHEMBL27267923 | 0.67 | KCNA5 (0.35) | KCNA5ALDH1A1MAPTKDM4ECYP2C19 | |
| SCHEMBL8889041 | 0.66 | MAPT (0.44) | KCNA5ALDH1A1MAPTKDM4EKCNH2 | |
| SCHEMBL8986648 | 0.66 | KCNA5 (0.49) | KCNA5ALDH1A1KDM4ECYP2C19KCNH2 | |
| SCHEMBL7293012 | 0.66 | KCNA5 (0.49) | KCNA5ALDH1A1KDM4ECYP2C19KCNH2 | |
| SCHEMBL29864658 | 0.65 | MAPT (0.55) | POLBKCNA5ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4803278-A | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |