Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502527 | 0.88 | TOP2A (0.44) | TOP2ANQO1ALDH1A1LMNAPOLB | |
| SCHEMBL10502841 | 0.84 | TOP2A (0.42) | TOP2ATOP2B | |
| SCHEMBL10502382 | 0.83 | CNR1 (0.36) | NQO1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL10920849 | 0.82 | TOP2A (0.53) | TOP2AALDH1A1LMNAPOLBMAPT | |
| SCHEMBL10502230 | 0.82 | NQO1 (0.51) | TOP2ANQO1ALDH1A1LMNAPOLB | |
| SCHEMBL10501981 | 0.82 | TOP2A (0.47) | TOP2ANQO1POLBMAPTTOP2B | |
| SCHEMBL10920060 | 0.74 | TOP2A (0.45) | TOP2ANQO1POLBMAPTTOP2B | |
| SCHEMBL10921696 | 0.74 | TOP2A (0.34) | TOP2ANQO1TOP2BBACE1 | |
| SCHEMBL10815656 | 0.72 | TOP2A (0.47) | TOP2ANQO1ALDH1A1LMNAPOLB | |
| SCHEMBL10502412 | 0.71 | TOP2A (0.45) | TOP2AALDH1A1POLBTOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | claimed |
| EP-0172632-A1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-26 | — | — | EP | claimed |
| EP-0172632-B1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0172632-A1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-26 | — | — | EP | disclosed |