Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483564 | 0.88 | TOP2A (0.41) | TOP2ANQO1TOP2B | |
| SCHEMBL8485627 | 0.88 | TOP2A (0.41) | TOP2AMAPTPOLBNQO1TOP2B | |
| SCHEMBL8486344 | 0.87 | TOP2A (0.40) | TOP2AMAPTPOLBALDH1A1LMNA | |
| SCHEMBL10815526 | 0.85 | TOP2A (0.37) | TOP2AMAPTNQO1ALDH1A1LMNA | |
| SCHEMBL10811696 | 0.84 | NQO1 (0.33) | TOP2ANQO1TOP2B | |
| SCHEMBL10812073 | 0.83 | TOP2A (0.49) | TOP2ATOP2B | |
| SCHEMBL10810510 | 0.83 | NQO1 (0.36) | TOP2ANQO1TOP2B | |
| SCHEMBL10809616 | 0.81 | TOP2A (0.61) | TOP2AMAPTPOLBALDH1A1LMNA | |
| SCHEMBL10927511 | 0.81 | NQO1 (0.46) | TOP2AMAPTPOLBNQO1ALDH1A1 | |
| SCHEMBL10655030 | 0.80 | NQO1 (0.49) | TOP2AMAPTPOLBNQO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | claimed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | claimed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |