Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501811 | 0.89 | MPI (0.48) | MPIPHOSPHO1METAP2ALDH1A1HTT | |
| SCHEMBL10502430 | 0.85 | METAP2 (0.44) | MPIPHOSPHO1METAP2CYP2A6 | |
| SCHEMBL10501737 | 0.82 | METAP2 (0.41) | MPIPHOSPHO1METAP2ALDH1A1HTT | |
| SCHEMBL10502224 | 0.81 | MPI (0.62) | MPIPHOSPHO1METAP2ALDH1A1HTT | |
| SCHEMBL10501435 | 0.79 | SMN1; SMN2 (0.45) | METAP2ALDH1A1TDP1MAPT | |
| SCHEMBL10502376 | 0.77 | MPI (0.69) | MPIPHOSPHO1METAP2ALDH1A1HTT | |
| SCHEMBL10501645 | 0.77 | MPI (0.54) | MPIPHOSPHO1METAP2ALDH1A1MAPT | |
| SCHEMBL10503039 | 0.76 | METAP2 (0.41) | MPIPHOSPHO1METAP2ALDH1A1HTT | |
| SCHEMBL10502616 | 0.76 | METAP2 (0.46) | MPIPHOSPHO1METAP2ALDH1A1HTT | |
| SCHEMBL10502354 | 0.76 | METAP2 (0.41) | MPIPHOSPHO1METAP2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |