Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KLK3 | P07288 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501763 | 0.88 | ALDH1A1 (0.44) | TSHRTDP1KMT2AALDH1A1LMNA | |
| SCHEMBL10503465 | 0.86 | METAP2 (0.52) | TDP1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL10501110 | 0.81 | METAP2 (0.47) | TSHRKMT2AALDH1A1LMNANPC1 | |
| SCHEMBL10502530 | 0.79 | MPI (0.41) | TDP1ALDH1A1MAPTMETAP2 | |
| SCHEMBL10502430 | 0.77 | METAP2 (0.44) | METAP2 | |
| SCHEMBL10502143 | 0.76 | METAP2 (0.45) | SMN1; SMN2TSHRTDP1KMT2AALDH1A1 | |
| SCHEMBL10501265 | 0.76 | MPI (0.49) | SMN1; SMN2TSHRTDP1KMT2AALDH1A1 | |
| SCHEMBL10501994 | 0.76 | POLB (0.52) | SMN1; SMN2ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL10502218 | 0.74 | CYP1A2 (0.47) | SMN1; SMN2TDP1ALDH1A1LMNANPC1 | |
| SCHEMBL10501811 | 0.74 | MPI (0.48) | TDP1KMT2AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |