Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 12/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502264 | 0.83 | POLB (0.46) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL7496921 | 0.79 | POLB (0.54) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL10501647 | 0.79 | POLB (0.44) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL10502194 | 0.78 | NPC1 (0.33) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL10501708 | 0.77 | POLB (0.41) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL10801353 | 0.72 | TOP2A (0.72) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL11750169 | 0.71 | TOP2A (0.38) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL10502223 | 0.71 | TOP2A (0.46) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL7495129 | 0.71 | TOP2A (0.50) | POLBNPC1RAD52RAB9AMITF | |
| SCHEMBL7488073 | 0.71 | TOP2A (0.50) | POLBNPC1RAD52RAB9AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172632-B1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |