Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502246 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 | |
| SCHEMBL10501790 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 | |
| SCHEMBL10501813 | 0.99 | CHRM4 (0.38) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 | |
| SCHEMBL10660765 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EHTTTSHR | |
| SCHEMBL10658208 | 0.86 | HIF1A (0.36) | SMN1; SMN2ALDH1A1CHRM4MAPTKDM4E | |
| SCHEMBL10503111 | 0.85 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 | |
| SCHEMBL10660811 | 0.84 | HTT (0.31) | HTT | |
| SCHEMBL7942147 | 0.84 | HTT (0.45) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 | |
| SCHEMBL10502390 | 0.83 | THRB (0.37) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 | |
| SCHEMBL10502296 | 0.81 | HTT (0.45) | SMN1; SMN2ALDH1A1NPC1PKMCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167817-B1 | 8-Alkylthio-2-piperazino-pyrimido[5,4-d]pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1989-09-20 | — | — | EP | disclosed |
| US-4714698-A | ANTITUMOR, ANTICOAGULANT | DR. KARL THOMAE GMBH (DE) | 1987-12-22 | — | — | US | disclosed |
| EP-0167817-A1 | 8-Alkylthio-2-piperazino-pyrimido[5,4-d]pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1986-01-15 | — | — | EP | disclosed |