SCHEMBL10503149

SCHEMBL10503149

O=C(C=C(c1c[nH]nn1)c1c[nH]nn1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.46
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
HDAC1 Q13547 2/20 0.41
HDAC2 Q92769 2/20 0.41
HDAC3 O15379 1/20 0.41
NCOR2 Q9Y618 1/20 0.41
ALDH1A1 P00352 3/20 0.40
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
AKT1 P31749 2/20 0.39
MMP9 P14780 1/20 0.38
LMNA P02545 2/20 0.37
F2 P00734 1/20 0.37
GAA P10253 2/20 0.37
MAPT P10636 5/20 0.36
RECQL P46063 2/20 0.36
PLIN1 O60240 1/20 0.36
BCHE P06276 1/20 0.36
TNFRSF1A P19438 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11403405 0.84 NFE2L2 (0.34) NFE2L2MEN1KMT2AHDAC1HDAC2
SCHEMBL947216 0.78 KMT2A (0.48) MEN1KMT2AALDH1A1TDP1LMNA
SCHEMBL11138598 0.77
Bicarbonate SCHEMBL15511345 0.76 KMT2A (0.47) MEN1KMT2AALDH1A1TDP1LMNA
SCHEMBL1690453 0.75 CYP19A1 (0.47) MEN1KMT2AALDH1A1MAPK1TDP1
SCHEMBL3012123 0.74 CYP1B1 (0.56) MEN1KMT2AHDAC1HDAC2HDAC3
SCHEMBL3012126 0.74 CYP1B1 (0.56) MEN1KMT2AHDAC1HDAC2HDAC3
SCHEMBL3230225 0.73 F2 (0.32) KMT2AALDH1A1MAPK1LMNAF2
SCHEMBL11697644 0.73 ESR1 (0.42) MEN1KMT2AALDH1A1TDP1LMNA
SCHEMBL11546766 0.73 ESR1 (0.40) MEN1KMT2AALDH1A1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0114626-B1 DITRIAZOLYLVINYL-PHENYL-KETONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN SLOWING DOWN NITRIFICATION BASF Aktiengesellschaft (DE) 1989-11-08 EP claimed
US-4550173-A NITRIFICATION INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1985-10-29 US claimed
US-4550173-A NITRIFICATION INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1985-10-29 US disclosed
US-4550173-A NITRIFICATION INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1985-10-29 US disclosed
US-4550173-A NITRIFICATION INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1985-10-29 US disclosed