Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503163 | 1.00 | HPGD (0.49) | HPGDSIGMAR1ESR1ESR2TLR8 | |
| SCHEMBL10502861 | 0.99 | HPGD (0.50) | HPGDSIGMAR1ESR1ESR2TLR8 | |
| SCHEMBL10502959 | 0.95 | HPGD (0.55) | HPGDESR1ESR2TLR8TLR7 | |
| SCHEMBL10503381 | 0.87 | SCN9A (0.44) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL10502715 | 0.87 | SCN9A (0.44) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| Enazadrem SCHEMBL635505 | 0.83 | ESR1 (0.51) | HPGDSIGMAR1ESR1ESR2TLR8 | |
| SCHEMBL11038908 | 0.83 | HDAC3 (0.46) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL10503330 | 0.82 | SCN9A (0.45) | HPGDESR1ESR2HDAC3HDAC1 | |
| SCHEMBL10503228 | 0.80 | DNM2 (0.44) | — | |
| SCHEMBL10504062 | 0.80 | DNM2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138464-B1 | 2-AMINO-5-HYDROXY-4-METHYLPYRIMIDINE DERIVATIVES | PFIZER INC. (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4673677-A | 2-AMINO-5-HYDROXY-4-METHYLPYRIMIDINE | PFIZER INC. (US) | 1987-06-16 | — | — | US | disclosed |
| US-4554276-A | ENZYME INHIBITORS, ANTIULCER AGENTS | PFIZER INC. (US) | 1985-11-19 | — | — | US | disclosed |
| EP-0138464-A2 | 2-Amino-5-hydroxy-4-methylpyrimidine derivatives | PFIZER INC. (US) | 1985-04-24 | — | — | EP | disclosed |