Enazadrem

Enazadrem

SCHEMBL635505

Cc1nc(NCCCCCCc2ccccc2)nc(C)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ ESR1 P03372 3/20 0.51
▸ ESR2 Q92731 3/20 0.51
▸ SIGMAR1 Q99720 4/20 0.50
▸ HPGD P15428 1/20 0.50
▸ HTR7 P34969 1/20 0.48
▸ TLR8 Q9NR97 1/20 0.48
▸ TLR7 Q9NYK1 1/20 0.48
▸ KCNH3 Q9ULD8 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13932020 0.94 HPGD (0.57) ESR1ESR2SIGMAR1HPGDHTR7
Enazadrem SCHEMBL219332 0.93 S1PR2 (0.49) ESR1ESR2SIGMAR1HPGDHTR7
SCHEMBL10503163 0.83 HPGD (0.49) ESR1ESR2SIGMAR1HPGDTLR8
SCHEMBL10503435 0.83 HPGD (0.49) ESR1ESR2SIGMAR1HPGDTLR8
SCHEMBL14215349 0.83 HPGD (0.48) ESR1ESR2SIGMAR1HPGDHTR7
SCHEMBL10367889 0.82 IGF1R (0.42) ESR1ESR2HPGD
SCHEMBL10502861 0.82 HPGD (0.50) ESR1ESR2SIGMAR1HPGDHTR7
SCHEMBL10800127 0.80 P2RX3 (0.48) SIGMAR1L3MBTL1
SCHEMBL10367691 0.79 ESR1 (0.50) ESR1ESR2
SCHEMBL10502959 0.77 HPGD (0.55) ESR1ESR2HPGDHTR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 272 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA PLUTO INC (KR) 2025-10-30 — — US claimed
EP-4494639-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA Pluto Inc. (KR) 2025-01-22 — — EP claimed
WO-2023177128-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA 주식회사 플루토 2023-09-21 — — WO claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 — — US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 — — US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 — — US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 — — US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 — — US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
EP-0888127-B1 COMBINATIONS HAVING IMMUNOSUPPRESSIVE EFFECTS, CONTAINING CYCLOOXYGENASE-2-INHIBITORS AND 5-LIPOXYGENASE INHIBITORS SEARLE & CO (US) 2001-12-12 — — EP claimed
US-4959365-A PENETRATION ENHANCING 1-ALKYLAZACYCLOHEPTAN-2-ONE OR CIS-OLEFINIC FATTY ACID,ESTER, ALCOHOL OR AMINE PFIZER INC. (US) 1990-09-25 — — US claimed
EP-2841109-B1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA AS (DK) 2026-04-15 — — EP disclosed
WO-1996038442-A1 SUBSTITUTED SULFONYLPHENYLHETEROCYCLES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS G.D. SEARLE & CO. (US) 1996-12-05 — — WO disclosed
US-4959365-A PENETRATION ENHANCING 1-ALKYLAZACYCLOHEPTAN-2-ONE OR CIS-OLEFINIC FATTY ACID,ESTER, ALCOHOL OR AMINE PFIZER INC. (US) 1990-09-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA MYOF, ALOX5, MYLK2 ESR1 2847/4885ESR2 1837/4885SIGMAR1 4815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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