Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 9/20 | 0.56 |
| ▸ | TLR4 | O00206 | 6/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503472 | 0.85 | MAPT (0.39) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| SCHEMBL10503551 | 0.85 | MAPT (0.39) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| SCHEMBL10503927 | 0.85 | ADRB3 (0.51) | ADRB3ADRB2ADRB1KDM4EHTR1A | |
| SCHEMBL10503765 | 0.84 | ADRB3 (0.40) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| SCHEMBL10504318 | 0.84 | ADRB2 (0.53) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| SCHEMBL10505739 | 0.82 | ADRB1 (0.44) | ADRB3ADRB2ADRB1KDM4EKMT2A | |
| SCHEMBL10506851 | 0.82 | ADRB2 (0.52) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| Carvedilol SCHEMBL3725960 | 0.81 | MAPT (0.70) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| SCHEMBL10505761 | 0.80 | ADRB3 (0.50) | ADRB3TLR4ADRB2DRD2ADRB1 | |
| SCHEMBL10504605 | 0.79 | ADRB3 (0.53) | ADRB3TLR4ADRB2DRD2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |