Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506813 | 0.80 | ESR1 (0.35) | MAOBMAOAFTOESR1ESR2 | |
| SCHEMBL11412674 | 0.78 | MAOB (0.50) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL29960477 | 0.76 | AR (0.49) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL29568413 | 0.76 | MAOB (0.48) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL1857840 | 0.76 | HTR2B (0.50) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL30111795 | 0.76 | HTR2B (0.50) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL546446 | 0.76 | MAOB (0.48) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL10506818 | 0.76 | MAOB (0.44) | MAOBMAOAFTOALDH1A1DYRK1A | |
| SCHEMBL10765471 | 0.76 | MAOB (0.48) | MAOBMAOAFTOALDH1A1KDM4E | |
| SCHEMBL28632877 | 0.73 | DYRK1A (0.37) | MAOBMAOAFTODYRK1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163227-B1 | 5-SUBSTITUTED CHROMONES AND THIOCHROMONES | MILES INC. (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4639535-A | INTERMEDIATES FOR ANTIALLERGENS | MILES LABORATORIES, INC. (US) | 1987-01-27 | — | — | US | disclosed |
| US-4571405-A | Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives, compositions, and method of use therefor | MILES LABORATORIES, INC. (US) | 1986-02-18 | — | — | US | disclosed |
| EP-0163227-A1 | 5-Substituted chromones and thiochromones | MILES INC. (US) | 1985-12-04 | — | — | EP | disclosed |