Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.54 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.77 |
| ▸ | FAAH | O00519 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.77 |
| ▸ | MTOR | P42345 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | HRH1 | P35367 | 7/20 | 0.54 |
| ▸ | HRH2 | P25021 | 6/20 | 0.54 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.54 |
| ▸ | DRD3 | P35462 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amperozide SCHEMBL340961 | 0.87 | CYP3A4 (1.00) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| Amperozide SCHEMBL1321270 | 0.86 | MEN1 (1.00) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| Amperozide SCHEMBL17360644 | 0.85 | CYP3A4 (0.95) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| Hydrochloric Acid SCHEMBL10510286 | 0.84 | MEN1 (0.83) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| Hydrochloric Acid SCHEMBL10510024 | 0.83 | KMT2A (0.81) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| Hydrochloric Acid SCHEMBL10507007 | 0.81 | MEN1 (0.78) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| SCHEMBL10506450 | 0.80 | MAPK1 (0.74) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| SCHEMBL10509222 | 0.78 | MAPK1 (0.72) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| Oxalic Acid SCHEMBL10934872 | 0.78 | MAPK1 (0.65) | MAPK1CYP3A4CYP2D6FAAHTSHR | |
| SCHEMBL10556167 | 0.78 | CYP3A4 (0.83) | MAPK1CYP3A4CYP2D6FAAHTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0136274-B1 | 1-PIPERAZINE CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | AB Ferrosan (SE) | 1989-11-08 | — | — | EP | disclosed |
| EP-0136274-A1 | 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions | AB Ferrosan (SE) | 1985-04-03 | — | — | EP | disclosed |