Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 8/20 | 0.53 |
| ▸ | NOS1 | P29475 | 5/20 | 0.34 |
| ▸ | TK1 | P04183 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | PAH | P00439 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278710 | 0.83 | HPRT1 (0.54) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL23892758 | 0.83 | HPRT1 (0.54) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9739844 | 0.83 | HPRT1 (0.60) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL1732936 | 0.83 | HPRT1 (0.63) | HPRT1PNP | |
| SCHEMBL10510121 | 0.83 | HPRT1 (0.52) | HPRT1NOS1TK1PNPNOS3 | |
| SCHEMBL8762573 | 0.81 | HPRT1 (0.70) | HPRT1PNP | |
| SCHEMBL3743947 | 0.80 | HPRT1 (0.56) | HPRT1NOS1NOS3NOS2USP2 | |
| SCHEMBL9124829 | 0.80 | HPRT1 (0.46) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL21637016 | 0.79 | HPRT1 (0.57) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL3836268 | 0.78 | HPRT1 (0.61) | HPRT1NOS1TK1PNPNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165289-B1 | NOVEL DERIVATIVES OF GUANINE | Medivir Aktiebolag (SE) | 1989-04-05 | — | — | EP | claimed |
| EP-0165289-A1 | NOVEL DERIVATIVES OF GUANINE. | ASTRA LAEKEMEDEL AB (SE) | 1985-12-27 | — | — | EP | claimed |
| WO-1985002845-A1 | NOVEL DERIVATIVES OF GUANINE | Astra Läkemedel Aktiebolag (SE) | 1985-07-04 | — | — | WO | claimed |
| EP-0146516-A2 | Derivatives of Guanine, process for their preparation and a pharmaceutical preparation | Astra Läkemedel Aktiebolag (SE) | 1985-06-26 | — | — | EP | claimed |
| EP-0165289-B1 | NOVEL DERIVATIVES OF GUANINE | Medivir Aktiebolag (SE) | 1989-04-05 | — | — | EP | disclosed |
| US-4798833-A | VIRICIDES | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1989-01-17 | — | — | US | disclosed |
| EP-0165289-A1 | NOVEL DERIVATIVES OF GUANINE. | ASTRA LAEKEMEDEL AB (SE) | 1985-12-27 | — | — | EP | disclosed |
| WO-1985002845-A1 | NOVEL DERIVATIVES OF GUANINE | Astra Läkemedel Aktiebolag (SE) | 1985-07-04 | — | — | WO | disclosed |
| EP-0146516-A2 | Derivatives of Guanine, process for their preparation and a pharmaceutical preparation | Astra Läkemedel Aktiebolag (SE) | 1985-06-26 | — | — | EP | disclosed |