Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177723 | 0.89 | LOXL2 (0.59) | TDP1TSHRRAB9ANPC1CA1 | |
| Toluene SCHEMBL27262094 | 0.80 | TDP1 (0.59) | TDP1TSHRRAB9ANPC1CA1 | |
| Methyl Benzoate SCHEMBL16041278 | 0.79 | TSHR (0.83) | TDP1TSHRRAB9ANPC1CA1 | |
| SCHEMBL9812040 | 0.78 | CA1 (0.51) | TSHRRAB9ANPC1CA1CA2 | |
| SCHEMBL5177245 | 0.78 | LOXL2 (0.58) | TDP1TSHRRAB9ANPC1CA1 | |
| SCHEMBL765010 | 0.77 | LOXL2 (0.61) | TDP1TSHRCA1CA2LOXL2 | |
| Methyl Benzoate SCHEMBL28005847 | 0.77 | TSHR (0.79) | TDP1TSHRRAB9ANPC1CA1 | |
| SCHEMBL4319657 | 0.77 | LOXL2 (0.53) | TDP1TSHRRAB9ANPC1CA1 | |
| SCHEMBL1428309 | 0.77 | CA1 (0.56) | TSHRRAB9ANPC1CA1CA2 | |
| SCHEMBL13113799 | 0.77 | LOXL2 (0.53) | TSHRRAB9ANPC1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140359-B1 | MORPHOLINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-01-25 | — | — | EP | disclosed |
| US-4783460-A | HYPOGLYCEMIC AGENTS, ANTIOBESITY AGENTS | BEECHAM GROUP P.L.C. (GB) | 1988-11-08 | — | — | US | disclosed |
| US-4665072-A | HYPOGLYCEMIC, ANTIOBESITY | BEECHAM GROUP P.L.C. (GB) | 1987-05-12 | — | — | US | disclosed |
| US-4607033-A | T EATING HYPERGLYCAEMIA AND-OR OBESITY | BEECHAM GROUP P.L.C. (GB) | 1986-08-19 | — | — | US | disclosed |
| EP-0140359-A1 | Morpholine derivatives | BEECHAM GROUP PLC (GB) | 1985-05-08 | — | — | EP | disclosed |