Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10509673 | 0.87 | CYP1A2 (0.48) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL10495487 | 0.85 | HSPB1 (0.51) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL9171793 | 0.82 | CYP1A2 (0.64) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL11092359 | 0.80 | PDE7A (0.53) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL4697642 | 0.80 | PPARG (0.52) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL10495582 | 0.80 | MAPT (0.39) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL8141281 | 0.78 | HSPB1 (0.57) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL29519502 | 0.78 | CYP1A2 (0.56) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 | |
| SCHEMBL28508933 | 0.77 | CYP1A2 (0.51) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL2395683 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C9CYP2C19ALDH1A1EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164694-B1 | N-BENZOYL-N'-PYRIMIDINYLOXYPHENYL UREA COMPOUNDS, AND ANTITUMOROUS COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1989-12-06 | — | — | EP | disclosed |
| US-4677110-A | N-benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1987-06-30 | — | — | US | disclosed |
| EP-0164694-A2 | N-Benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1985-12-18 | — | — | EP | disclosed |