Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1190798 | 0.98 | HSD11B1 (0.46) | HSD11B1ALDH1A1L3MBTL1BCHENR1I2 | |
| SCHEMBL20207115 | 0.89 | KMT2A (0.41) | HSD11B1ALDH1A1L3MBTL1BCHEHTT | |
| SCHEMBL16275225 | 0.86 | NPSR1 (0.47) | HSD11B1ALDH1A1L3MBTL1NR1I2HTT | |
| SCHEMBL26999845 | 0.85 | HTT (0.44) | HSD11B1ALDH1A1L3MBTL1NR1I2HTT | |
| SCHEMBL28794057 | 0.85 | BCHE (0.40) | HSD11B1ALDH1A1L3MBTL1BCHENR1I2 | |
| SCHEMBL26999847 | 0.85 | ALDH1A1 (0.43) | HSD11B1ALDH1A1L3MBTL1NR1I2HTT | |
| SCHEMBL4072176 | 0.84 | ALDH1A1 (0.51) | HSD11B1ALDH1A1L3MBTL1BCHENR1I2 | |
| SCHEMBL21673398 | 0.84 | ALDH1A1 (0.51) | HSD11B1ALDH1A1L3MBTL1BCHENR1I2 | |
| SCHEMBL13523706 | 0.84 | ALDH1A1 (0.51) | HSD11B1ALDH1A1L3MBTL1BCHENR1I2 | |
| SCHEMBL5970194 | 0.83 | HSD11B1 (0.44) | HSD11B1ALDH1A1L3MBTL1NR1I2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0156191-B1 | CONDENSED DIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1989-07-19 | — | — | EP | disclosed |
| US-4550107-A | Condensed diazepinones, their compositions and methods of use as pharmaceuticals | DR. KARL THOMAE GMBH (DE) | 1985-10-29 | — | — | US | disclosed |
| EP-0156191-A2 | Condensed diazepinones, process for their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-10-02 | — | — | EP | disclosed |