Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.43 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | HTR1B | P28222 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440636 | 0.82 | HTR1B (0.49) | MRGPRX4MAOAMAOBHTR1BIDO1 | |
| SCHEMBL4440531 | 0.80 | HTR1B (0.46) | MRGPRX4MAOAMAOBHTR1BIDO1 | |
| SCHEMBL47973 | 0.78 | CTNNB1 (0.43) | MRGPRX4HTR1BCTNNB1WNT3A | |
| SCHEMBL12344285 | 0.77 | CYP2A6 (0.45) | MRGPRX4MAOAMAOBHTR1BCTNNB1 | |
| SCHEMBL48789 | 0.77 | HTR1B (0.41) | MRGPRX4MAOAMAOBHTR1B | |
| SCHEMBL16140300 | 0.76 | HTR1B (0.46) | MAOAMAOBHTR1BCTNNB1WNT3A | |
| SCHEMBL10507927 | 0.76 | HTR1B (0.50) | HTR1BCTNNB1WNT3A | |
| SCHEMBL1602111 | 0.76 | HTR1B (0.53) | MRGPRX4HTR1BIDO1CTNNB1WNT3A | |
| Benzofuran SCHEMBL28622200 | 0.76 | TSHR (0.56) | KCNA3KCNA5KCNA1MRGPRX4MAOA | |
| SCHEMBL3818271 | 0.75 | HTR1B (0.43) | HTR1BCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152340-B1 | 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4544667-A | CARBONIC ANHYDRASE INHIBITOR; VISION DEFECTS | MERCK & CO., INC. (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0152340-A1 | 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |