Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 15/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10511031 | 0.90 | ALOX15 (0.44) | ALOX15HSD17B10PTGDR2MAPT | |
| SCHEMBL10511806 | 0.86 | ALOX15 (0.50) | ALOX15HSD17B10PTGDR2AKR1B1 | |
| SCHEMBL10652713 | 0.84 | LMNA (0.49) | MAPT | |
| SCHEMBL10511834 | 0.81 | MEN1 (0.43) | AKR1B1MAPT | |
| SCHEMBL10509370 | 0.77 | TP53 (0.36) | ALOX15HSD17B10PTGDR2AKR1B1 | |
| SCHEMBL10507148 | 0.75 | ALOX15 (0.53) | ALOX15HSD17B10PTGDR2MAPT | |
| SCHEMBL10648782 | 0.75 | LMNA (0.57) | MAPT | |
| SCHEMBL10509886 | 0.74 | HSD17B3 (0.44) | ALOX15HSD17B10PTGDR2 | |
| SCHEMBL4328088 | 0.72 | NPY5R (0.51) | PTGDR2 | |
| SCHEMBL10508894 | 0.72 | ALOX15 (0.41) | ALOX15HSD17B10PTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162776-B1 | HETEROCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS USEFUL AS ALDOSE REDUCTASE INHIBITORS CONTAINING THEM | LABORATOIRES UPSA (FR) | 1989-04-19 | — | — | EP | disclosed |
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |