Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 5/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.40 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28335609 | 0.79 | CYP1A2 (0.60) | TDP1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL31530995 | 0.76 | NUDT1 (0.40) | ABL1CYP1A2HSP90AA1 | |
| SCHEMBL31530991 | 0.76 | NUDT1 (0.40) | ABL1CYP1A2HSP90AA1 | |
| SCHEMBL31530990 | 0.76 | CYP1A2 (0.46) | TDP1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL20742185 | 0.76 | LATS1 (0.39) | LATS1LATS2CCNCCDK8ABL1 | |
| SCHEMBL20742551 | 0.76 | LATS1 (0.39) | LATS1LATS2CCNCCDK8TDP1 | |
| SCHEMBL11001632 | 0.75 | LATS1 (0.46) | LATS1LATS2CCNCCDK8ABL1 | |
| SCHEMBL23646296 | 0.74 | ROCK2 (0.41) | LATS1LATS2CCNCCDK8ABL1 | |
| SCHEMBL20742393 | 0.73 | SMN1; SMN2 (0.46) | LATS1LATS2CCNCCDK8TDP1 | |
| SCHEMBL9698346 | 0.72 | CYP1A2 (0.45) | TDP1S1PR1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0108380-B1 | PYRIDO 2,3-D PYRIDIMIN-5-ONES | STERLING DRUG INC. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4560753-A | 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0108380-A2 | Pyrido 2,3-d pyridimin-5-ones | STERLING DRUG INC. (US) | 1984-05-16 | — | — | EP | disclosed |
| US-4432981-A | 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones | STERLING DRUG INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-RE30024-E | ANTIALLERGENS | STERLING DRUG INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4118571-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-10-03 | — | — | US | disclosed |
| US-4109092-A | FROM PYRIDINYL-CARBOXAMIDINE AND ALPHA-CHLOROACRYLONITRILE | STERLING DRUG INC. (US) | 1978-08-22 | — | — | US | disclosed |
| US-4086233-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4053475-A | ANTI-ALLERGIC AGENTS | STERLING DRUG INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4032523-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
| US-4018770-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-4008235-A | ANTIALLERGIC | STERLING DRUG INC. (US) | 1977-02-15 | — | — | US | disclosed |
| US-3992380-A | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters | STERLING DRUG INC. (US) | 1976-11-16 | — | — | US | disclosed |