Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10510083 | 1.00 | FLT3 (0.43) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| Bromide SCHEMBL10581709 | 0.99 | FLT3 (0.42) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| Bromide SCHEMBL10581715 | 0.99 | FLT3 (0.42) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| Bromide SCHEMBL10583382 | 0.96 | MAOA (0.43) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| Bromide SCHEMBL10583385 | 0.96 | MAOA (0.43) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| SCHEMBL10581084 | 0.94 | KAT2B (0.42) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| SCHEMBL10581087 | 0.94 | KAT2B (0.42) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| Bromide SCHEMBL10582244 | 0.93 | KAT2B (0.41) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| Bromide SCHEMBL10582253 | 0.93 | KAT2B (0.41) | FLT3MAOAMAOBSMN1; SMN2LMNA | |
| SCHEMBL10509576 | 0.88 | KCNH2 (0.41) | FLT3LMNAHRH3KCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | claimed |
| EP-0164593-B1 | ANTI-INFLAMMATORY PHTHALAZINONES | FISONS CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| EP-0309765-A2 | 1(2H)-Phthalazinones as cytoprotective agents | FISONS CORPORATION (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4769369-A | Anti-allergy 1(2H)-phthalazinones | PENNWALT CORPORATION (US) | 1988-09-06 | — | — | US | disclosed |
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0164593-A1 | Anti-inflammatory phthalazinones | FISONS CORPORATION (US) | 1985-12-18 | — | — | EP | disclosed |