Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10583385 | 1.00 | MAOA (0.43) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| Bromide SCHEMBL10581709 | 0.97 | FLT3 (0.42) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| Bromide SCHEMBL10581715 | 0.97 | FLT3 (0.42) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| SCHEMBL10510083 | 0.96 | FLT3 (0.43) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| SCHEMBL10510092 | 0.96 | FLT3 (0.43) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| Bromide SCHEMBL10582253 | 0.93 | KAT2B (0.41) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| Bromide SCHEMBL10582244 | 0.93 | KAT2B (0.41) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| SCHEMBL10581087 | 0.92 | KAT2B (0.42) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| SCHEMBL10581084 | 0.92 | KAT2B (0.42) | MAOAMAOBFLT3LMNASMN1; SMN2 | |
| Bromide SCHEMBL10353541 | 0.87 | EGFR (0.40) | MAOAMAOBSMN1; SMN2EGFRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309765-A2 | 1(2H)-Phthalazinones as cytoprotective agents | FISONS CORPORATION (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4769369-A | Anti-allergy 1(2H)-phthalazinones | PENNWALT CORPORATION (US) | 1988-09-06 | — | — | US | disclosed |