Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10876388 | 0.83 | HDAC8 (0.52) | HDAC8CYP19A1KCNA5POLBCYP3A4 | |
| SCHEMBL10972042 | 0.82 | CHRNB2 (0.54) | HDAC8OPRK1SMN1; SMN2MEN1CYP1A2 | |
| Ethylene SCHEMBL9547378 | 0.78 | HDAC8 (0.48) | HDAC8CYP19A1KCNA5MEN1CYP1A2 | |
| SCHEMBL11464003 | 0.76 | CYP2C9 (0.62) | HDAC8SMN1; SMN2POLBMEN1CYP1A2 | |
| SCHEMBL10968614 | 0.76 | CYP2C9 (0.42) | HDAC8CYP19A1KCNA5OPRK1CYP51A1 | |
| SCHEMBL9547383 | 0.76 | HDAC8 (0.46) | HDAC8CYP19A1KCNA5MEN1CYP1A2 | |
| SCHEMBL10967991 | 0.75 | SMN1; SMN2 (0.53) | CYP19A1KCNA5SMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL24069228 | 0.74 | MEN1 (0.53) | HDAC8CYP19A1KCNA5OPRK1POLB | |
| SCHEMBL11092434 | 0.74 | IDO1 (0.44) | HDAC8CYP19A1KCNA5POLBCYP3A4 | |
| SCHEMBL10968611 | 0.73 | IDO1 (0.50) | CYP19A1OPRK1CYP51A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302366-A2 | Substituted pyridine derivatives | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |