Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 8/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10510567 | 0.90 | PTGS1 (0.39) | PTGS1GPBAR1MAPTHTR7KDM4E | |
| SCHEMBL10511337 | 0.89 | LMNA (0.34) | GPBAR1MAPTGLAKRASALDH1A1 | |
| SCHEMBL10510160 | 0.82 | PTGS1 (0.37) | PTGS1GPBAR1MAPTHTR7DPP4 | |
| SCHEMBL10660755 | 0.80 | GPBAR1 (0.40) | PTGS1GPBAR1MAPTHTR7KDM4E | |
| SCHEMBL10731910 | 0.71 | GPBAR1 (0.36) | PTGS1GPBAR1MAPTHTR7GLA | |
| SCHEMBL10512473 | 0.71 | CYP17A1 (0.39) | PTGS1MAPTKDM4EGLAGAA | |
| SCHEMBL11557039 | 0.70 | PTGS1 (0.43) | PTGS1GPBAR1MAPTHTR7GABRA1 | |
| SCHEMBL10655935 | 0.69 | ESR1 (0.52) | PTGS1GPBAR1HTR7LMNA | |
| SCHEMBL11557665 | 0.69 | PTGS1 (0.41) | PTGS1GPBAR1MAPTHTR7KDM4E | |
| SCHEMBL10659627 | 0.68 | PTGS1 (0.41) | PTGS1GPBAR1MAPTHTR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205872-B1 | FUROBENZISOXAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 1989-04-19 | — | — | EP | disclosed |
| US-4791209-A | DIURETICS, HYPOTENSIVE AGENTS | Chugai Seiyako Kabushiki Kaisha (JP) | 1988-12-13 | — | — | US | disclosed |
| EP-0205872-A1 | Furobenzisoxazole derivatives | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-12-30 | — | — | EP | disclosed |