Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 8/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15376219 | 0.85 | KEAP1 (0.60) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL10511429 | 0.84 | KEAP1 (0.58) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL31370539 | 0.79 | CPB2 (0.58) | KEAP1CPB2RETDAONAMPT | |
| SCHEMBL10513057 | 0.78 | KEAP1 (0.55) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL2049672 | 0.78 | KEAP1 (0.68) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL14638413 | 0.78 | KEAP1 (0.68) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL74518 | 0.78 | KEAP1 (0.68) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL22715097 | 0.77 | NAMPT (0.45) | KEAP1RETNAMPTSSTR4 | |
| Ammonia Solution, Strong SCHEMBL28922912 | 0.76 | KEAP1 (0.66) | KEAP1CPB2RETDAOMEN1 | |
| SCHEMBL15882447 | 0.75 | NAMPT (0.59) | KEAP1RETNAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499631-B | Preparation method of olprinone hydrochloride key intermediate 1-imidazo [1,2-a ] pyridin-6-yl-2-acetone | 济南康桥医药科技有限公司 | 2021-07-30 | — | — | CN | claimed |
| CN-111499631-A | Preparation method of olprinone hydrochloride key intermediate | 山东美泰医药有限公司 | 2020-08-07 | — | — | CN | claimed |
| JP-63077879-A | — | — | None | — | — | JP | disclosed |
| CN-114773341-A | Preparation method of olprinone hydrochloride | 河北爱尔海泰制药有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-111499631-B | Preparation method of olprinone hydrochloride key intermediate 1-imidazo [1,2-a ] pyridin-6-yl-2-acetone | 济南康桥医药科技有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-111499631-A | Preparation method of olprinone hydrochloride key intermediate | 山东美泰医药有限公司 | 2020-08-07 | — | — | CN | disclosed |
| EP-0199127-B1 | 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative | Eisai Co., Ltd. (JP) | 1989-12-13 | — | — | EP | disclosed |
| US-4803276-A | CARDIOTONIC AGENTS, VASODILATION | EISAI CO., LTD. (JP) | 1989-02-07 | — | — | US | disclosed |
| US-4791202-A | CARDIOTONIC AGENTS; CONGESTIVE HEART FAILURE | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4791203-A | CARDIOTONIC AGENTS | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4751227-A | 3-cyano-5-(6-imidazo[1,2-a]pyridyl)pyridin-2-ols useful as cardiotonics | EISAI CO., LTD. (JP) | 1988-06-14 | — | — | US | disclosed |
| JP-S6377879-A | 1-(IMIDAZO(1,2-A)PYRIDIN-6-YL)-2-PROPANONE DERIVATIVE | EISAI CO LTD | 1988-04-08 | — | — | JP | disclosed |
| EP-0199127-A1 | 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative | Eisai Co., Ltd. (JP) | 1986-10-29 | — | — | EP | disclosed |