⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14139660 | 0.83 | — | — | |
| SCHEMBL27693349 | 0.83 | — | — | |
| SCHEMBL7005702 | 0.75 | — | — | |
| SCHEMBL20069033 | 0.75 | — | — | |
| SCHEMBL319529 | 0.73 | — | — | |
| SCHEMBL2951642 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL7483196 | 0.73 | GAA (0.36) | — | |
| SCHEMBL86860 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL19747840 | 0.71 | OPRM1 (0.34) | — | |
| SCHEMBL1515058 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571203-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2018136661-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-07-26 | — | — | WO | disclosed |
| US-20180134703-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
| EP-0343307-A1 | 4-Piperidinealkanamine derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (ES) | 1989-11-29 | — | — | EP | disclosed |
| EP-0114658-B1 | ALKYL-SUBSTITUTED 4-METHYL-PIPERIDINE DERIVATIVES AND USE THEREOF AS STABILIZERS | AUSIMONT S.p.A. (IT) | 1988-07-27 | — | — | EP | disclosed |
| US-4621110-A | Alkyl-substituted 4-methyl-piperidine derivatives and use thereof as stabilizers | MONTEDISON S.P.A. (IT) | 1986-11-04 | — | — | US | disclosed |
| EP-0114658-A1 | Alkyl-substituted 4-methyl-piperidine derivatives and use thereof as stabilizers | AUSIMONT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |