⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951642 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL17749000 | 0.75 | OPRM1 (0.34) | — | |
| SCHEMBL13321357 | 0.75 | — | — | |
| SCHEMBL10514616 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL19747840 | 0.75 | OPRM1 (0.34) | — | |
| SCHEMBL26622624 | 0.75 | — | — | |
| SCHEMBL1753867 | 0.72 | TSHR (0.43) | — | |
| SCHEMBL20069036 | 0.71 | CHRM2 (0.34) | — | |
| SCHEMBL16451672 | 0.71 | DRD4 (0.30) | — | |
| SCHEMBL3506624 | 0.71 | NCF1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113583021-B | Synthesis method of spiropiperidine rifamycin | 漯河启福医药科技有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-113583021-A | Synthesis method of spiropiperidine rifamycin | 四川樵枫科技发展有限公司 | 2021-11-02 | — | — | CN | disclosed |
| US-20200187500-A1 | PYRIDINE COMPOUNDS | BASF SE (DE) | 2020-06-18 | — | — | US | disclosed |
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |