Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10514668 | 1.00 | PIM1 (0.59) | PIM1PIM2HDAC4HPGDAKR1B1 | |
| SCHEMBL10515952 | 0.89 | HDAC4 (0.54) | PIM1PIM2HDAC4HPGDAKR1B1 | |
| SCHEMBL10515957 | 0.89 | HDAC4 (0.54) | PIM1PIM2HDAC4HPGDAKR1B1 | |
| SCHEMBL10514674 | 0.88 | CLK1 (0.44) | PIM1PIM2HDAC4HPGDCLK1 | |
| SCHEMBL10514536 | 0.85 | IGF1R (0.49) | PIM1PIM2HDAC4HPGDAKR1B1 | |
| SCHEMBL10514534 | 0.85 | IGF1R (0.49) | PIM1PIM2HDAC4HPGDAKR1B1 | |
| SCHEMBL10515906 | 0.79 | CLK1 (0.54) | HDAC4HPGDCLK1DYRK1ADYRK1B | |
| SCHEMBL10512908 | 0.78 | PIM1 (0.59) | PIM1PIM2HDAC4AKR1B1IGF1R | |
| SCHEMBL10519079 | 0.78 | PIM1 (0.59) | PIM1PIM2HDAC4AKR1B1IGF1R | |
| SCHEMBL1247957 | 0.77 | PIM1 (0.46) | PIM1PIM2HPGDIGF1RCISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299620-A1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1989-01-18 | — | — | EP | claimed |
| EP-0299620-A1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1989-01-18 | — | — | EP | disclosed |